Five Questions With: Robert Hurt

Robert Hurt is an engineering professor at Brown University and the director of the university’s Institute for Molecular and Nanoscale Innovation, which just celebrated its five-year anniversary.

Hurt talked to Providence Business News about the institute’s growth during that period, its research, and the future of the nanoscience industry in the Ocean State.

PBN: As director of the Institute for Molecular and Nanoscale Innovation at Brown, how has this program grown in the five years since its inception?

HURT: Our Institute, IMNI, was founded in 2007 to promote and coordinate research and education in the molecular and nanosciences across the Brown campus.

Over the last five years we have worked hard to develop cross-departmental and cross-institutional research teams that allow our scientist to address the big societal problems of the day – those that are too complex for traditional single-investigator science.

We have also recruited and hired several new young faculty members, developed a professional staff for proposal development and program management, increased the number and breadth of our federal grant portfolio in this area, acquired new major pieces of research equipment, and launched the Rhode Island Consortium for Nanoscience and Nanotechnology (RIN2) together with partners from URI.

PBN: Of all the research being conducted at IMNI, what’s your favorite and why?

HURT: It’s a hard choice - with 60 members and three thrust areas, we have a lot of exciting research to talk about. Certainly Professor Shouheng Sun’s research on nanoparticle synthesis is internationally recognized, and his highly engineered nanoparticles are promising for applications in sensing, data storage, fuel cell electrodes, biomedicine, and as catalysts for energy transformation processes.

Another highlight is our new federally-sponsored Center for Chemical Innovation, led by Professor Tayhas Palmore. The grant focuses on conversion of carbon dioxide in the atmosphere into commodity chemicals, in the hope of developing more sustainable routes to chemical manufacturing.

I am also very excited by our industry partnerships with General Motors and Medtronic, both focused on advanced materials.

PBN: IMNI recently earned permission from the university to open a NanoTools facility on campus, what does that entail?

HURT: One of IMNI’s most important functions has been to build and operate central facilities that offer state-of-the-art equipment to users both on and off campus. Much of the equipment needed for modern R&D in nanotechnology and materials science is too expensive to be acquired and run by individual investigators or laboratories. IMNI currently operates central facilities for micro-fabrication and electron microscopy, the latter facility being one of the finest university facilities anywhere.

A while back we recognized the need for a new facility that focuses on material characterization. Having fabricated a new material or device, one needs to know a lot about its structure and properties before it can be effectively pushed into new technologies. Our new NanoTools facility, which is on the planning board, will house a suite of state-of-the-art instruments for materials characterization, including spectroscopies to study the chemical bonding within a material, and atomic force microscopes to study the atomic-scale and nanoscale features on material surfaces.

PBN: The science of nanotechnology has really burst onto the scene in the last 20 years, how do you think the field will continue to grow, both at IMNI and nationally?

HURT: Nanotechnology has grown steadily over the last decade both in terms of federal funding and in terms of IP generation and product commercialization. This growth is projected to continue. At the same time, nanotechnology has matured and evolved as a field, and become less of a stand-alone activity and more integrated into technology development across a range of sectors.

I believe that most nanotechnology today is not being practiced at self-identified nanotech startups, but at large firms in many different sectors of manufacturing. Much of the R&D you might associate with energy technology, for example, whether in batteries, solar cells, or fuel cells, is really nanotechnology applied to the materials and components used in those devices. That is where much of the real innovation is occurring.

Ten years ago, nanotechnology was exploratory science taking place in university laboratory settings, and sometimes described in very imaginative and futuristic terms. Now it is evolving into a set of practical mainstream tools and materials used in technology development for energy, health care, military, and manufacturing. I believe we will see continued growth, but that growth might not always be in the form of an easily definable nanotech business sector.

PBN: You’ve said that you think nanotechnology can help Brown (and the state’s other higher education facilities) boost Rhode Island’s economy. How?

HURT: IMNI’s growth has created faculty and staff jobs, as mentioned above. I think our biggest opportunity for the future is still in the area of federal funding, where IMNI and RIN2 can bring together a critical mass of researchers to compete for large grants.

This basic research employs people in the state, and also attracts some of the top young talent to pursue higher degrees and maybe remain in the state or region after graduation. I also hope we can grow our industrial partner program and focus it more on state and regional companies.

Finally, with the establishment of the new School of Engineering, which is a major player in IMNI, and with Brown’s development and growth in the Jewelry District, there is hope we can develop a critical mass of high-technology activity in Providence that could help the knowledge economy here take shape.

By Emily Greenhalgh

Grant for Chemical Innovation Center

Researchers at Brown have been awarded $1.75 million to explore the potential of using carbon dioxide instead of fossil fuels in the production of common industrial chemicals. Advances could reduce the chemical industry’s carbon footprint and help stabilize production costs in the face of ever increasing fuel prices. 

“The goal is to find new ways to produce some of the world’s largest-volume chemicals from a sustainable carbon source that the earth not only has in excess but urgently needs to reduce,” said Tayhas Palmore, professor of engineering and principal investigator on the grant.

The funding comes from the National Science Foundation’s Centers for Chemical Innovation Program. The research team includes Wesley Bernskoetter, Christoph Rose-Petruck, Dwight Sweigart, and Shouheng Sun from the Department of Chemistry, as well as Robert Hurt and Andrew Peterson from the School of Engineering and Nilay Hazari from the Department of Chemistry at Yale. The team is administered by Brown’s Institute for Molecular and Nanoscale Innovation (IMNI).

Small Wonder

Partnering with an engineer, a pathologist goes in a new direction.

The yellow-and-black signs outside Dr. Agnes Kane’s pathology laboratory read “CAUTION: Cancer hazard.” Nodding at the ominous-looking postings, Kane explains, “because of their toxicity similar to asbestos, we handle these materials as if they were carcinogens.” Meanwhile, across the Providence River, at the School of Engineering, Professor Robert Hurt is hard at work creating the very materials that Kane is so gingerly studying: nanoparticles.

Smaller than 1,000th the width of a human hair—so small that you need an electron microscope to see them— nanoparticles’ practical applications may be enormous: making implants more biocompatible; diagnosing and treating cancers; cleaning up oil spills. That said, the history of science is filled with promising solutions that create additional unforeseen problems of their own. No one is more aware of this than Kane, chair of Brown’s Department of Pathology and Laboratory Medicine. She has spent her career on, and helped guide the Department’s focus on, the human health effects of environmental and occupational exposures. She and Hurt tick off some examples demonstrating this law of unintended consequences:

“Corn ethanol,” says Hurt, referring to the fact that 40 percent of the corn grown in America is used to create this alternative fuel. “Then you raise the corn prices for food.”

Kane nods. “Use more fertilizer? Contaminate our water supplies. There’s always these trade-offs.”

One of modern history’s most devastating trade-offs was of a common mineral that makes an excellent flameretardant building material. Its usefulness notwithstanding, asbestos can cause devastating cancers and fatal lung problems both for those who mine it and for those who live and work in buildings that contain it.

Small, Novel...but Safe

Selenium-carbon nanocomposite particles
synthesized as a novel chemotherapy agent

From the time Kane joined Brown’s pathology department as a founding member in 1982, she has studied the mechanisms by which asbestos injures cells and causes cancer. When, in 2004, she gave a talk about this research to a group of colleagues, Hurt approached her afterward. The asbestos fibers that Kane showed in her talk reminded Hurt of the carbon nanofibers he had been developing. “We were not working on health effects at the time,” Hurt says. “We were doing traditional nanoscience, trying to make new things that had never been made before.”

But when Hurt told Kane about his carbon nanofibers, “I immediately asked him if I could have some,” Kane recalls. Her worrisome discovery—that the particles were similar to asbestos in several key ways—has changed the direction of both her own and Hurt’s careers and of the pathology department’s research and teaching.

Now Kane and Hunt work side-by-side to create innovative nanotechnology and, simultaneously, assess the materials’ safety and toxicity. “It’s a new paradigm to try to consider the implications of the technology as you develop the technology,” says Hurt. “We haven’t done a lot of that in the past. We just develop technology and we field it and then we worry about what its implications might be. So it’s kind of fun to do these things together.”

In 2007, their collaboration gave rise to the Institute for Molecular and Nanoscale Innovation (IMNI), an interdisciplinary organization comprising more than 60 faculty in nine departments. Kane heads IMNI’s NanoHealth Initiative, which studies the environmental and health effects of nanotechnology.

Training the Next Interdisciplinarians

With curly chin-length gray hair and blue eyes, Kane—known to friends and colleagues as “Aggie”—smiles often and laughs readily. Her unassuming manner and commitment to collaboration, teaching, and mentorship have won her numerous teaching awards and devotees.

“If it weren’t for Aggie, I wouldn’t be doing what I’m doing,” says Luba Dumenco, a lecturer in pathology and director of the Medical School’s preclinical curriculum. “She’s always valued teaching incredibly highly.” Just recently, Dumenco struck up a conversation with another mom at the local skating rink.The woman happened to be a neonatologist who had trained at Brown’s medical school. “I told her I was teaching at the med school, and she said, ‘Do you know Dr. Aggie Kane? She was our favorite! We loved her!’” Dumenco says with a laugh. “She cares a lot about the students.She does a wonderful job and they’re very lucky to have her.”

The breadth of students that Kane reaches each year has grown as a result of her partnership with Hurt. In 2009, they secured a grant from GAANN, or Graduate Assistance in Areas of National Need, to fund interdisciplinary training in nanotechnology. Between six and eight doctoral students study nanotoxicology and nanomedicine with co-mentors in engineering or physical sciences and biological science. Kane and Hurt also co-teach an undergraduate and graduate course called “Small Wonders: Science, Technology, and Human Health Impacts of Nanomaterials.” For their final projects, students working together in interdisciplinary teams are required both to use nanotechnology to solve some real-world problem and to address—and minimize—their solution’s potential environmental and health impacts. “I look at this as training the next generation of environmental scientists and engineers,” Kane says.

But first they have to learn how to talk to each other. When Kane and Hurt began collaborating, “it took us a while to learn each other’s languages,” says Kane, “because medicine has its own vocabulary, as well as engineering.” Kane might, for example, say “mitochondria,” or “epigenetics,” and get a blank stare in return. “And so we would just keep asking each other questions, any time we didn’t understand something,” she recalls. “It took us quite some time to learn enough to communicate effectively.”

Their newest collaboration is funded by the Gulf of Mexico Research Initiative, which was established in the wake of the Deepwater Horizon disaster. Hurt has set out to design nanoparticles called nanosorbents, which by capturing and sequestering pollutants like oil, may be safer and more effective than existing methods of cleaning up oil spills. The Deepwater Horizon cleanup team—like the Exxon Valdez team before it—relied on Corexit, a dispersant which causes oil to suspend in the water as tiny particles rather than accumulate on the surface as oil slicks.

“They used it in enormous amounts in the Deepwater Horizon cleanup,” says Hurt, but “it’s not clear if it’s a good idea to use very large amounts of chemicals in a marine environment.”

But it’s not clear whether nanosorbents are a good idea, either. As Hurt designs the particles, Kane and her team set out to answer two questions. “First, will they work?” she asks. “And then, will they be toxic to the organisms?”

“They might be worse,” Hurt acknowledges. “We don’t know.”

Engineering Prevention

To begin to answer these questions, Kane has a small steel tank in her lab. Like a miniature wave pool, the open-air tank bubbles with seawater maintained at exactly 72 degrees. Soon this will be home to a small colony of brine shrimp, tiny marine organisms that, as larvae in the wild, are eaten by small fish, which, in turn, are used as bait to catch larger fish, which are eaten by people. As such, the brine shrimp are a good “indicator species” for study.

“We don’t want to have these kinds of dispersants accumulate up the food chain,” says Kane, peeking at the churning water.

A tube runs from a beaker into the basin, helping to aerate the water. As the shrimp grow in the lab, Kane and her colleagues will release oil and Hurt’s nanoparticles into the water with them to see what happens. Will they stop swimming? Will they die? Will their RNA reflect toxicity or injury? If so, Kane says, she is confident that her colleagues can alter the nanoparticles to reflect her findings.

“Engineers are very clever,” she says with a smile. “If we can identify the specific properties that are associated with the toxic effects, they can design [the nanoparticles] or process them to eliminate those properties or reduce those properties and reduce their toxicity.” And part of the excitement of studying nanoparticles is the ability to intervene now, in the very early stages—to prevent environmental and health disasters, rather than clean them up after the fact.

“When you think about what happened with the widespread use of asbestos throughout the 20th century— and we’re still suffering the consequences because of the long latent period of those diseases—the fact that those fibers persist in the buildings and in the environment and we’re still being exposed,” says Kane, “that’s a very expensive lesson. We do not want to repeat that tragedy again.”

by Beth Schwartzapfel ’01
Photographs by Karen Philippi
Courtesy of Brown Medicine Magazine

Brown/IMNI Part of Consortium Awarded $450,000 to Research Deepwater Horizon Oil Spill in Gulf of Mexico

The Institute for Molecular and Nanoscale Innovation (IMNI) at Brown University is part of a consortium, led by Gulf State partner Tulane University, that has been selected to receive funding as part of the Gulf of Mexico Research Initiative (GRI-BP) program to address future large-scale petroleum spills. The Brown / IMNI sub-award is $450,000 and focuses on particle-based alternatives to chemical dispersants.


Media contact: Dr. Robert Gropp
gripress@aibs.org

Reston, VA – Research on the effects of the Deepwater Horizon oil spill in the Gulf of Mexico took a major step forward today with the Gulf of Mexico Research Initiative (GRI) Research Board’s announcement that eight Research Consortia will be funded for the next three years. A total of $112.5 million over three years will support this portion of the GRI research effort. These teams will investigate the fate of petroleum in the environment, the impacts of the spill, and the development of new tools and technology for responding to future spills and improving mitigation and restoration.

The grant recipients announced today were selected using a competitive merit-review process.

The GRI Research Board is an independent body established by BP to administer the company’s 10-year, $500 million commitment to independent research into the effects of the Deepwater Horizon incident. Through a series of competitive grant programs, the GRI is investigating the impacts of the oil, dispersed oil, and dispersant on the ecosystems of the Gulf of Mexico and the affected coastal States in a broad context of improving fundamental understanding of the dynamics of such events and their environmental stresses and public health implications. The GRI also funds research that improves techniques for detecting oil and gas, spill mitigation, and technologies to characterize and remediate spills. Knowledge accrued will be applied to restoration and to improving the long-term environmental health of the Gulf of Mexico.

“I know the research community has been awaiting this announcement,” said Dr. Rita R. Colwell, Chairman of the GRI Research Board. “The GRI worked aggressively to develop RFP-I to ensure that we stimulate critically important research. The GRI has continued to work relentlessly to receive and review grants in order to make this announcement by the deadline we set last April.”

The grants awarded today were in response to RFP-I, a request for proposals the GRI Research Board issued on April 25, 2011. This request for proposals solicited applications from Research Consortia –
groups of researchers with compatible expertise from four or more institutions – to address one or more of the five intellectual themes established by the GRI Research Board. These themes are: 1) Physical distribution, dispersion, and dilution of petroleum, its constituents, and associated contaminants under the action of physical oceanographic processes, air-sea interactions, and tropical storms; 2) Chemical evolution and biological degradation of the petroleum/dispersant systems and subsequent interaction with coastal, open-ocean, and deep-water ecosystems; 3) Environmental effects of the petroleum/dispersant system on the sea floor, water column, coastal waters, beach sediments, wetlands, marshes, and organisms, and the science of ecosystem recovery; 4) Technology developments for improved responses, mitigation, detection, characterization, and remediation associated with oil spills and gas releases; and 5) Fundamental scientific research integrating results from the other four themes in the context of public health.

“These Consortia establish a research community of great strength with promise of substantial achievement. The results will illuminate the consequences of the Deepwater Horizon explosion and spill, and enable appropriate responses should there be future releases not only in the Gulf of Mexico, but anywhere that oil and gas is produced in ocean environments. They will also assist local, state and federal agencies in their work to remediate the consequences of the oil spill in coastal and marine environments. The long term contribution of this research will be of major benefit to industry, governments, and the people who live along the Gulf of Mexico coast,” said Colwell.

“The GRI received a number of excellent proposals,” said Colwell; “Following a competitive merit review process the Research Board approved funding for eight Research Consortia. These groups will be funded for the next three years and will then be eligible to apply for additional funding.”

The Research Consortia funded are:

Lead Institution: The University of Texas at Austin, Marine Science Institute.
Lead Investigator: Edward J. Buskey, Ph.D.
Project Title: “The Impact of Biological, Physical and Chemical Processes on the Fate of Oil Spills – bridging small scale processes with meso-scale modeling,”
Member Institutions: The Johns Hopkins University, University of Pennsylvania, University of Minnesota, SINTEF Norway, University of Wisconsin-Milwaukee, Research Applied Technology Education Services (Rates)/Coastal Oil Spill Simulation System (COSS)

Lead Institution: Texas A&M University at College Station.
Lead Investigator: Piers Chapman, Ph.D.
Project Title: “Gulf of Mexico Integrated Spill Response Consortium.”
Member Institutions: Massachusetts Institute of Technology, Stanford University, University of California at Berkeley, North Carolina State University, University of Texas at Austin, Woods Hole Oceanographic Institution, University of Hawaii at Manoa, University of Maryland, Georgia Institute of Technology

Lead Institution: Florida State University.
Lead Investigator: Eric Chassignet, Ph.D. Project Title: “Deep-C: Deepsea to Coast Connectivity in the Eastern Gulf of Mexico.”
Member Institutions: Dauphin Island Sea Lab, Florida Institute of Oceanography, Georgia Institute of Technology, Naval Research Laboratory, Norwegian Meteorological Institute, Science Applications
International Corporation, University of South Florida, University of West Florida, University of Miami, Woods Hole Oceanographic Institution

Lead Institution: Louisiana Universities Marine Consortium.
Lead Investigator: Nancy N. Rabalais, Ph.D.
Project Title: “The Effects of the Macondo Oil Spill on Coastal Ecosystems.”
Member Institutions: Brigham Young University, Connecticut College, Florida Gulf Coast University, Louisiana State University Agricultural Center, Louisiana State University, Woods Hole Oceanographic Institution, Rutgers-The State University of New Jersey, University of Louisiana at Lafayette, University of Maryland, University of Tennessee, Virginia Institute of Marine Science

Lead Institution: University of South Florida.
Lead Investigator: Jacqueline Dixon, Ph.D.
Project Title: “Center for Integrated Modeling and Analysis of the Gulf Ecosystem (C-IMAGE).”
Member Institutions: Eckerd College, University of West Florida, Florida Institute of Oceanography, Texas A&M University, Florida State University, University of Miami, Mote Marine Laboratory, North Carolina State University, University of California at Los Angeles, University of California at San Diego, Pennsylvania State University, Leibniz Institute, Hamburg University of Technology, NHL University of Applied Sciences, University of Calgary, Wageningen University

Lead Institution: University of Miami.
Lead Investigator: Tamay Özgökmen, Ph.D.
Project Title: “Consortium for Advanced Research of Hydrocarbon Transport in the Environment (CARTHE).”
Member Institutions: City University of New York, Staten Island, Florida International University, Florida State University, Naval Postgraduate School, Naval Research Laboratory, Nova Southeastern University, Texas A&M University-Corpus Christi, Tulane University, University of Arizona, University of Delaware, University of Texas at Austin

Lead Institution: Tulane University.
Lead Investigator: Vijay T. John, Ph.D.
Project Title: “The Science and Technology of Dispersants as Relevant to Deep Sea Oil Releases.”
Member Institutions: University of South Florida, Carnegie Mellon University, University of Texas at Austin, University of Rhode Island, Princeton University, Auburn University, Louisiana State University, City University of New York, University of Houston, University of Minnesota, University of Buffalo, Arizona State University, University of Massachusetts at Amherst, North Carolina State University, Brown University, University of Michigan, University of Colorado at Boulder, University of Southern Mississippi, University of Maryland, Florida International University, Georgetown University, Princeton University

Lead Institution: University of Mississippi.
Lead Investigator: Raymond Highsmith, Ph.D.
Project Title: “Ecosystem Impacts of Oil and Gas Inputs to the Gulf (ECOGIG).”
Member Institutions: University of Southern Mississippi, University of Georgia, Florida State University, Georgia Institute of Technology, Temple University, Oregon State University, Pennsylvania State
University, Columbia University, University of Maryland, University of North Carolina at Chapel Hill, University of California at Santa Barbara, University of Texas at Austin, J. Craig Venter Institute

This is the second round of funding the GRI has provided this year. On June 30, 2011, the Research Board awarded 17 grants totaling $1.5 million to support the time-sensitive acquisition of critical samples and observations associated with the Deepwater Horizon oil spill on the Gulf of Mexico. Funding for these grants was awarded under the terms of an emergency request for proposals, RFP-III. There will be an additional opportunity for researchers to pursue funding from the GRI. Colwell advised, “The GRI is working to develop and issue another request for proposals, RFP-II, which will award approximately $7.5 million a year in smaller grants to individual or small teams of researchers.”
________________________________
The GRI Research Board members are:
Rita R. Colwell, Ph.D., Research Board Chair
Margaret Leinen, Ph.D., Research Board Vice Chair
Debra S. Benoit, M.Ed.
Peter G. Brewer, Ph.D.
Richard E. Dodge, Ph.D.
John W. Farrington, Ph.D.
Kenneth M. Halanych, Ph.D.
David Halpern, Ph.D.
William T. Hogarth, Ph.D.
Jörg Imberger, Ph.D.
Raymond L. Orbach, Ph.D.
Jürgen Rullkötter, Ph.D.
David R. Shaw, Ph.D.
John Shepherd, Ph.D.
Bob Shipp, Ph.D.
Burton Singer, Ph.D.
Ciro V. Sumaya, M.D., MPHTM
Denis Wiesenburg, Ph.D.
Charles Wilson, Ph.D.
Dana Yoerger, Ph.D.

For more information about the GRI or the Research Board, please visit:
www.griresearchboard.org .

Nickel nanoparticles may contribute to lung cancer

Lab experiments find that nickel particles with diameters billionths of a meter wide can trigger a cellular pathway that promotes cancer growth.

PROVIDENCE, R.I. [Brown University] — All the excitement about nanotechnology comes down to this: Structures of materials at the scale of billionths of a meter take on unusual properties. Technologists often focus on the happier among these newfound capabilities, but new research by an interdisciplinary team of scientists at Brown University finds that nanoparticles of nickel activate a cellular pathway that contributes to cancer in human lung cells.

When human lung epithelial cells are exposed to equivalent doses of nano-sized (left) or micro-sized (right) metallic nickel particles, activated HIF-1 alpha pathways (stained green) appear mostly with the nanoparticles.

“Nanotechnology has tremendous potential and promise for many applications,” said Agnes Kane, chair of the Department of Pathology and Laboratory Medicine in The Warren Alpert Medical School of Brown University. “But the lesson is that we have to learn to be able to design them more intelligently and, if we recognize the potential hazards, to take adequate precautions.”

Kane is the senior author of the study published in advance online this month in the journal Toxicological Sciences.

Nickel nanoparticles had already been shown to be harmful, but not in terms of cancer. Kane and her team of pathologists, engineers and chemists found evidence that ions on the surface of the particles are released inside human epithelial lung cells to jumpstart a pathway called HIF-1 alpha. Normally the pathway helps trigger genes that support a cell in times of low oxygen supply, a problem called hypoxia, but it is also known to encourage tumor cell growth.

“Nickel exploits this pathway, in that it tricks the cell into thinking there’s hypoxia but it’s really a nickel ion that activates this pathway,” said Kane, whose work is supported by a National Institues of Health Superfund Research Program Grant. “By activating this pathway it may give premalignant tumor cells a head start.”

Size matters

The research team, led by postdoctoral research associate and first author Jodie Pietruska, exposed human lung cells to nanoscale particles of metallic nickel and nickel oxide, and larger microscale particles of metallic nickel. A key finding is that while the smaller particles set off the HIF-1 alpha pathway, the larger metallic nickel particles proved much less problematic.

In other words, getting down to the nanoscale made the metallic nickel particles more harmful and potentially cancer-causing. Kane said the reason might be that for the same amount of metal by mass, nanoscale particles expose much more surface area and that makes them much more chemically reactive than microscale particles.

Another important result from the work is data showing a big difference in how nickel nanoparticles and nickel oxide nanoparticles react with cells, Pietruska said. The nickel oxide particles are so lethal that the cells exposed to them died quickly, leaving no opportunity for cancer to develop. Metallic nickel particles, on the other hand, were less likely to kill the cells. That could allow the hypoxia pathway to lead to the cell becoming cancerous.

“What is concerning is the metallic nickel nanoparticles caused sustained activation but they were less cytotoxic,” Pietruska said. “Obviously a dead cell can’t be transformed.”

Although Kane said the findings should raise clear concerns about handling nickel nanoparticles, for instance to prevent airborne exposure to them in manufacturing, they are not all that’s needed to cause cancer. Cancer typically depends on a number of unfortunate changes, Kane said. Also, she said, the study looked at the short-term effects of nickel nanoparticle exposure in cells in a lab, rather than over the long term in a whole organism.

Still, in her lab Kane employs significant safeguards to keep researchers safe.

“We handle all these materials under biosafety level 2 containment conditions,” she said. “I don’t want anyone exposed. We’re handling them as though they were an airborne carcinogen.”

In addition to Kane and Pietruska, other authors on the paper are Ashley Smith, Kevin McNeil, and Anatoly Zhitkovich, a toxicologist; chemist Xinyuan Liu; and engineer Robert Hurt. Kane, Hurt, and Zhitkovich are associated with Brown’s Institute for Molecular and Nanoscale Innovation.