Showing posts with label bme. Show all posts
Showing posts with label bme. Show all posts

Tuesday, January 29, 2013

Brown Engineering Student Cory Hargus Wins Award at National Collegiate Research Conference

Brown engineering student Cory Hargus ’13.5 has won an Award of Excellence and a $250 prize at the second annual National Collegiate Research Conference at Harvard on January 26, 2013. He entered the poster presentation competition with his research titled, “Solar Enriched Biofuels Via Oxidizable Metal Catalysts.” Hargus was one of more than 200 students entering the poster competition.

A biomedical engineering concentrator, Hargus is a member of the AIChE (American Institute of Chemical Engineers) student group at Brown and a research assistant in the Peterson Catalyst Lab.

“Since the day he joined our group, Cory has continued to surprise me with the level of sophistication he employs in his research,” said Andrew Peterson, assistant professor of engineering. “He started this work as a 'side project' while he helped with experimental work, but he quickly broadened it into a sophisticated and innovative analysis, teaching himself the key concepts in thermodynamics and electronic structure he needed to succeed. The recognition he received in Cambridge this weekend is well-deserved.”

Friday, March 23, 2012

Brown Graduate Student Lucy Weng ScB'08 Wins Award at the Northeast Bioengineering Conference

Brown University biomedical engineering graduate student Lucy Weng ScB'08 recently won the Master's Student Competition at the 2012 Northeast Bioengineering Conference hosted by Temple University in Philadelphia. Overall, there were more than 200 papers accepted, and awards were given for best paper to two master's student and two Ph.D. students. Weng received a certificate and a $250 prize.

Her paper, “Nanophase Magnesium for Orthopedic Applications” discusses the use of magnesium as a biomaterial for orthopedic applications because of its biocompatibility, biodegradability, and positive effect on bone formation. Likewise, studies have shown nanophase material increase osteoblast (bone-forming cell) function compared to conventional materials, but the two have not been studied together. The purpose of this study was to determine if altering magnesium surface features into the nanometer scale promotes greater osteoblast functions.

Nanorough magnesium surfaces were created by a novel treatment with sodium hydroxide at 1N, 5N, and 10N concentrations for 10, 20, and 30 minutes. Material characterization by scanning electron microscopy showed increased roughness on all treated samples compared to the control magnesium. Contact angle measurements indicated greater hydrophilicity on treated magnesium and no significant effect of ultraviolet sterilization on the surface energy of the material. Osteoblasts were seeded onto treated and untreated surfaces and adhesion at 4hrs were assessed through the MTT assay.

Results indicated increased osteoblast adhesion on nano-treated samples compared to untreated samples. These findings support previous studies indicating the promise of magnesium as a biomaterial for orthopedic applications and suggest further experiments examining the long-term effects of nanophase magnesium on osteoblast proliferation and function.

Three Biomedical Engineering Graduate Students Win Award

Brown biomedical engineering graduate students Gozde Durmus, Kim Kummer '11, and Erik Taylor were one of ten graduate student teams to win the Prize for Primary Healthcare Award (Phase I) from the Center for Integration of Medicine and Innovative Technology (CIMIT). The title of their project is "Using Nano-material Science to Inhibit Medical Device Infections".

Each winning team received $10,000, and they will now be able to use these funds to develop a final proposal over the next few months as they compete for the top three spots and a total of $300,000 in additional funds against teams from other top schools such as MIT, Johns Hopkins, and Yale.

“This is an outstanding achievement,” said Associate Professor Thomas Webster, “and places Brown among the top biomedical programs in the country.” Webster serves as the advisor to the three students on the research.

The award is for innovative technology ideas to improve the quality and efficiency of primary care in medicine. The Brown team was selected out of 76 applicants from 38 of the top engineering programs in the country. The goal of the competition is to stimulate the development of innovative technology to serve the needs of the frontlines of healthcare.

Thursday, March 22, 2012

Johnson & Johnson Corporate Office of Science & Technology Grant to Seed Biomedical Research

Brown announced that it has received an unrestricted grant from the Johnson & Johnson Corporate Office of Science & Technology (COSAT) to extend its seed funding for scientific research projects that have the potential to benefit patients and the healthcare system. Working with COSAT, Brown will identify projects, such as potential therapies, devices, or diagnostics, and then Brown will match funds from the grant to support the research.

“We're tremendously excited about launching this new translational seed fund,” said Katherine Gordon, who directs the university’s technology ventures office. “The funding dedicated to the new initiative will support grants for promising programs that require funding for proof of concept, feasibility or translational studies. We're very appreciative of this funding." 

Brown will retain all intellectual property rights to the research.

Wednesday, November 9, 2011

Erik Taylor Wins BMES Graduate Student Award

At the annual meeting of the Biomedical Engineering Society, Brown University graduate student Erik Taylor won the Graduate Student Extended Abstract Award for outstanding research. His submission, “Superparamagnetic Iron Oxide Nanoparticles Could Be Better than Antibiotics at Reducing Biofilm Produced by Staphylococcus Aureus” was considered by the committee strong enough to be only one of ten such awards presented.

This award consists of a certificate, a stipend of $500, and complimentary registration for the 2011 BMES Annual Meeting. The certificate was presented at the awards ceremony at the BMES Business Meeting on Thursday, October 13, 2011, in Hartford, Conn. The award has been presented each year since 1992 in recognition of outstanding biomedical engineering research.

Taylor, who was selected for a Fulbright Fellowship, will be leaving for India next semester to work on biofilm research and anti-infection strategies at IIT-Bombay in Mumbai for nine months. He will be working with Dr. Rinti Banerjee from IIT-Bombay through the Indo-U.S. Center for Biomaterials for Healthcare, co-directed by professors Bikram Basu and Thomas Webster.


Tuesday, September 13, 2011

Bioengineering Professor Leads Research on Head Impacts and Concussions in Football

Researchers, including biomedical engineering Professor Joseph J. "Trey" Crisco,  gathered data on the frequency, direction, and magnitude of head impacts from players who wore sensor-equipped helmets during three football seasons at Brown University, Dartmouth College, and Virginia Tech. The data amount to a measure of players’ exposure to head impacts, which can ultimately help physicians and scientists understand how concussions occur.


PROVIDENCE, R.I. — Thousands of college football players began competing around the nation this week, but with the thrill of the new season comes new data on the risks of taking the field. A new study reports that running backs and quarterbacks suffer the hardest hits to the head, while linemen and linebackers are hit on the head most often. The researchers measured head blows during games and practices over three seasons at Brown University, Dartmouth College, and Virginia Tech.

The study, led by Joseph J. Crisco, professor of orthopaedics in the Warren Alpert Medical School of Brown University and director of the bioengineering laboratory at Rhode Island Hospital, documented 286,636 head blows among 314 players in the 2007-09 seasons. Crisco said the new data on the magnitude, frequency, and location of head blows amounts to a measure of each player’s head impact exposure. Ultimately it can help doctors understand the biomechanics of how blows to the head result in injury.

“This allows us to quantify what the exposure is,” Crisco said. “It is the exposure that we need to build upon, so that we can then start understanding what the relationships are with acute and chronic head injury.”

The study appears online in advance in the Journal of Biomechanics.

Concussions and other head injuries have become a source of elevated concern in football and other sports in recent years, with various leagues revising policies to protect players better. In part based on seeing this new data, said Robin Harris, Ivy League executive director, league officials announced earlier this year that full-contact practices would be limited to two a week.

Hits by position


The new study documents the nature of head blows by player position. Players on the three teams wore helmets equipped with wireless sensors that measured acceleration in various directions. That data allowed the team of researchers from Brown, Dartmouth, Virginia Tech, and sensor-maker Simbex to discern how hard the hit was, how often each player was hit, and where on the helmet they were hit.

Crisco devised the algorithm that Simbex’s Head Impact Telemetry System uses to measure head impacts. The system’s development and this study were funded by the National Institute of Child Health and Human Development and the National Operating Committee on Standards for Athletic Equipment.

The data on head acceleration and hit direction are used to calculate a composite score of exposure called HITsp that researchers believe might be a good predictor of concussion. On average, running backs had the highest HITsp, 36.1, followed by quarterbacks with 34.5 and linebackers at 32.6. Offensive and defensive linemen had the lowest HITsp numbers, with 29.0 and 28.9 respectively, but along with linebackers, they were hit on the head most often. Doctors worry not only about hit severity, but also hit frequency, because repeated head impacts may cause “subconcussive” neurological damage over time.

By analyzing head impacts by position, Crisco said, researchers can help football league officials and equipment designers begin to think about ways to make players safer.

“It will allow us to begin to understand how to control the exposures,” Crisco said. Controlling head impact exposure is critical, he added, because there are currently no treatments for acute or chronic brain injuries, and helmets cannot prevent injuries for all players in all situations.

One possibility could include rule changes. Another could include designing helmets for specific positions.

Crisco and his colleagues are now analyzing data about concussions during the three seasons to determine how and whether head impact exposure is associated with injury. He recently co-authored another paper about male and female collegiate hockey players, which reported that although women were diagnosed with more concussions, they sustained fewer and less severe head impacts.

Although Crisco’s analysis is still underway, his insights into head impact exposure led him and co-author Richard Greenwald, a Dartmouth engineer, to write a commentary earlier this year in Current Sports Medicine Reports, in which they argued that intentional use of the head in sports must be curbed.

“We propose the adoption of rules — or in some sports, we champion the enforcement of existing rules — that eliminate intentional head contact in helmeted sports,” they wrote. “When coupled with education that leads to modified tackling, blocking, or checking techniques, these rules will reduce head impact exposure and have the potential to reduce the incidence and severity of brain injury.”

Crisco, a former college football and lacrosse player, said he is passionate about contact sports and believes they have many benefits.

“Hitting is an essential component,” he said. “But intentional hitting with your head was never part of any sport and is poor technique.”

In addition to Crisco and Greenwald, other authors of the paper are Bethany Wilcox of Brown; Jonathan Beckwith and Jeffrey Chu of Simbex; Stefan Duma and Steve Rowson of Virginia Tech and Wake Forest; and Ann-Christine Duhaime, Arthur Maerlender, and Thomas McAllister of Dartmouth.

By David Orenstein

Wednesday, August 31, 2011

Brown University Biomedical Engineering Program Receives ABET Accreditation

After a complete review, the undergraduate program in biomedical engineering at Brown University has received ABET accreditation.

“This represents a major accomplishment for the Center of Biomedical Engineering, the School of Engineering and the Division of Biology and Medicine,” said Dean Larry Larson.

The external ABET evaluation team examined all aspects of the curricula, student outcomes and feedback from alumni and students.

“This is a well deserved recognition of excellence,” said Edward Wing, Dean of the Warren Alpert Medical School, “and an acknowledgement that Biomedical Engineering brings together faculty from Engineering, BioMed and our affiliated hospitals for an outstanding curriculum.”

The review was led by Professors Anubhav Tripathi and Jeffrey Morgan, co-directors of the Center of Biomedical Engineering with assistance from faculty, staff and students who worked on the preparation of the materials for the review.

“As an Ivy League university competing for today’s brightest students and faculty, Brown biomedical engineering offers an opportunity for scholarship in a burgeoning multidisciplinary context where the synthesis of life sciences and engineering creates new knowledge and real solutions for modern medical care,” said Tripathi. 

Tuesday, October 12, 2010

Tsang selected for Biomedical Engineering Society Undergraduate Student Award

Biomedical Engineering (BME) Undergraduate student Melissa Tsang has been selected for the Biomedical Engineering Society Undergraduate Student Award to be presented October 6th, 2010 in Austin, TX at the Biomedical Engineering Society Annual Meeting. Undergraduate student winners will be selected on the basis of originality, significance, thoroughness of design analysis, and performance evaluation. This award is based on research conducted in Prof. Tom Webster's lab entitled "Novel Polyurethane/Carbon Nanofiber Composites for Bladder Cancer Applications." She has developed materials that can inhibit bladder cancer cell functions by using nanomaterials alone (specifically, carbon nanofibers, no pharmaceutical drugs are used.)

When Melissa first arrived at Brown, she chose to study BME because previous volunteering experiences had exposed her to the imbalance between current biotechnology and unmet medical needs. She wanted to develop the necessary analytical skills and foundation in biology to design innovative, improved technologies to expand upon our current diagnostics and treatments. As a senior approaching the end of her studies at Brown, she now feels better equipped to tackle this endeavor. In particular, working in Dr. Webster's lab has taught her how to construct and to conduct a research project independently. The opportunity to present her research at conferences, where she can meet many other BMEs in the field, is a rewarding experience for her. She feels that Brown engineering has provided her with not only the necessary skill sets, but also the hands-on experience and exposure to the forefront of current biomedical research to advance her career and, more importantly, to create solutions to better serve our global community.

Wednesday, August 5, 2009

Tissue engineering research at Brown

Codirector of Brown University’s Center for Biomedical Engineering, Jeff Morgan leads a team of scientists who have developed novel ways of forming individual cells into living tissue. Some day, their techniques, in combination with stem-cell technology, could cure or lessen the suffering of diabetes and other debilitating diseases.

Strictly speaking, Morgan is a tissue engineer –– one of a substantial number of scientists around the world who are learning how to create groupings of cells that mimic the function of tissues or organs. Formed in the laboratory, these tissues can be transplanted into living creatures. Research is still largely confined to experimental animals –– but success so far in mice and rats holds great promise for humans.

Morgan’s advance is his unique method of growing and assembling individual cells into larger clusters –– what he calls the potential “building blocks” of tissues and organs that could be produced on demand.

More from the Providence Journal here:
http://www.projo.com/news/content/tissue_man_08-03-09_O4F81UM_v10.3b3bef6.html

Thursday, July 2, 2009

Liu wins Acta Biomaterialia Graduate Student Award

Huinan Liu (Brown BME Graduate) was just selected as the Acta Biomaterialia Graduate Student Award winner for her paper:

"An in vitro evaluation of the Ca/P ratio for the cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration”, Acta Biomaterialia 2008; 4:1472-1479.

Acta Biomaterialia currently has the 2nd highest journal impact factor in the Materials Science, Biomaterials category.

The award letter reads:
"The field of nominees was very impressive, and the task of selecting a winner was challenging. Not only did your paper demonstrate exceptional value to the biomaterials community, which was also evidenced by its download ranking, but your personal credentials and recommendations were also exemplary. We will present this award at the 2009 Materials Science & Technology Meeting in Pittsburgh in October."

Tuesday, May 19, 2009

Biosensor to Measure Vitamin D Levels

A team from Professor Palmore's lab consisting of two grad students (Steve Rhieu and Vince Siu) and one undergraduate (Daniel Ludwig, '09) is in the Finalist round of the BMEIdea 2009 competition on June 9th – June 11th, in New York City, New York. This work was made possible by an OVPR seed grant and has a preliminary patent application submitted.

Here is the brief project summary:

We propose a new methodology to measure vitamin D levels in serum using electrochemical detection. Vitamin D is a prohormone that is hydroxylated in the liver to become 25(OH)D, which is further hydroxylated in the kidney by the enzyme CYP27B1 to become the biologically active form. The electrochemical approach is based on the hypothesis that the hydroxylation of 25(OH)D can be measured via the catalytic reaction of CYP27B1 immobilized on an electrode. The reaction requires a supply of electrons, generating a detectable current that is proportional to the concentration of 25(OH)D. Similar to a commercial glucose meter, our proposed vitamin D biosensor will use a disposable testing strip that is inserted in the portable device along with a sub-microliter sample. The sample is analyzed and the result is displayed both qualitatively and quantitatively on a liquid crystal display. Specific recognition of 25(OH)D by a CYP27B1-based electrode system eliminates the need for extensive extraction and/or purification of the sample allowing for inexpensive, accurate, and rapid measurements.