Prof. Sheldon and Webster appear in cover story

Brian Sheldon, Thomas Webster, and Lei Yang appeared as the cover story for the American Ceramic Society Bulletin. It is entitled " Nanophase Ceramics for Improved Drug Delivery: Current Opportunities and Challenges."

After more than a decade of research and development, nanotechnology has reshaped the traditional thinking (or lack thereof) of using ceramics for drug delivery. Although drug delivery has been a polymer- dominated field, the blossoming of nanotechnology means that ceramic materials are now showing much promise for numerous drug delivery applications.

Typically, nanotechnology is defined as the use of materials and systems whose structures and components exhibit novel and significantly changed properties when control is gained at the nanoscale (specifically, <100 nm or <10–7 m).1 For ceramics, this means fabricating ceramics whose grain or particle
sizes are within the range of 1 nm to 100 nm).

Nanophase ceramics already have been widely used in a broad spectrum of biomedical applications, and now drug delivery is one of the fastest emerging and developing arenas for nanoceramics, drawing increasing attention over the past few years.

Read more of the story at this link:
http://ceramics.org/wp-content/uploads/2010/03/03_10_cover-story.pdf

Hurt and Webster publish "Business and Safety Issues in the Commercialization of Nanotechnology"

Professors Bob Hurt and Tom Webster just published the book "Business and Safety Issues in the Commercialization of Nanotechnology," Materials Research Society Symposium Proceedings, Volume 1209, 2010. Editors are: L. Tsakalakos, L. Merhari, S. Mao, J. van Schijndel, T. J. Webster, H. Liu, and R. Hurt. (H. Liu is a recent Ph.D. graduate from Brown engineering).

More information on the book can be found at: http://www.mrs.org/s_mrs/sec_subscribe.asp?CID=24653&DID=271618

Collaborative project highlighted in premier neuroscience journal

The February issue of the journal Neuron features a cover story highlighting the joint work between Professors Arto Nurmikko and Barry Connors. Neuron is a premier journal in Neuroscience.

This is another illustration of the collaboration between Engineering and Biology and Medicine here at Brown. Arto Nurmikko's group has successfully led the initiative to bring the ‘optogenetics’ methodology to Brown.

Professor Allan Bower publishes new book, Applied Mechanics of Solids

Professor Allan Bowers new book, Applied Mechanics of Solids, comes out today, October 1, 2009.

Applied Mechanics of Solids summarizes the physical laws, mathematical methods, and computer algorithms that are used to predict the response of materials and structures to mechanical or thermal loading.

Topics include: the mathematical descriptions of deformation and forces in solids; constitutive laws; analytical techniques and solutions to linear elastic and elastic-plastic boundary value problems; the use and theory of finite element analysis; fracture mechanics; and the theory of deformable rods, plates and shells.

Over 400 practice problems are provided on a companion web site, as well as demonstration finite element codes in MAPLE and MATLAB. The text is intended for advanced undergraduate or graduate students, as well as practicing engineers and scientists. It will be particularly useful to readers who wish to learn enough about solid mechanics to impress their teachers, colleagues, research advisors, or managers, but who would prefer not to study the subject in depth.

An electronic version of the text can be accessed at http://solidmechanics.org and its also available from Amazon.

Nanoparticles eliminate bacterial infection on prosthetic

Infected implants now have a foe. Brown University researchers have created a nanoparticle that can penetrate a bacterial-produced film on prosthetics and kill the bacteria. The finding, published in the International Journal of Nanomedicine, is the first time that iron-oxide nanoparticles have been shown to eliminate a bacterial infection on an implanted prosthetic device.

Press release here: http://news.brown.edu/pressreleases/2009/06/biotechnology

Resulted in July 9th Providence Journal story: http://www.projo.com/education/content/BROWN_CANNONBALLS_07-09-09_5EEVHR2_v9.3015298.html
Nano “cannonballs” bash infected implants
Patients suffering from infected prostheses may now have an ally in tiny “cannonballs.” The nanoparticles created by graduate student Erik Taylor and engineering associate professor Thomas Webster have been shown in lab tests to kill bacteria that congregate on implants.

Hydrodynamics of Microorganisms

Professor Powers' article, Hydrodynamics of Swimming Mircoorganisms, was accepted this week in Reports on Progress in Physics.
Preview the article here: http://dl.getdropbox.com/u/652169/reviseLaugaPowersv3.pdf
Abstract.
Cell motility in viscous fluids is ubiquitous and affects many biological processes, including reproduction, infection, and the marine life ecosystem. Here we review the biophysical and mechanical principles of locomotion at the small scales relevant to cell swimming, tens of microns and below. At this scale, inertia is unimportant and the Reynolds number is small. Our emphasis is on the simple physical picture and fundamental flow physics phenomena in this regime. We first give a brief overview of the mechanisms for swimming motility, and of the basic properties of flows at low Reynolds number, paying special attention to aspects most relevant for swimming, such as resistance matrices for solid bodies, flow singularities, and kinematic requirements for net translation. Then we review classical theoretical work on cell motility, in particular early calculations of swimming kinematics with prescribed stroke and the application of resistive-force theory and slender-body theory to flagellar locomotion. After examining the physical means by which flagella are actuated, we outline areas of active research, including hydrodynamic interactions, biological locomotion in complex fluids, the design of small-scale artificial swimmers, and the optimization of locomotion strategies.

In addition, some of his recent work was highlighted on the NSF news page:
Scientists studying how marine bacteria move have discovered that a sharp variation in water current segregates right-handed bacteria from their left-handed brethren, impelling the microbes in opposite directions. This finding and the possibility of quickly and cheaply implementing the segregation of two-handed objects in the laboratory could have a big impact on industries like the pharmaceutical industry, for which the separation of right-handed from left-handed molecules can be crucial to drug safety.
More here: http://www.nsf.gov/news/news_summ.jsp?cntn_id=114587&org=NSF&from=news