Monday, December 21, 2009

Professor Franck studies cellular movement

Our cells are more like us than we may think. They’re sensitive to their environment, poking and prodding deliberately at their surroundings with hand-like feelers and chemical signals as they decide whether and where to move. Such caution serves us well but has vexed engineers who seek to create synthetic tissue, heart valves, implants and other devices that the human body will accept.

To overcome that obstacle, scientists have sought to learn more about how cells explore what’s around them. While numerous studies have looked at cellular movement in two dimensions and a few recent experiments involved cellular motion in three dimensions, scientists remained unsure just how much cells interacted with their surroundings. Now, a study involving Brown University and the California Institute of Technology has recorded for the first time how cells move in three dimensions by measuring the force exerted by cells on their environs. The research gives scientists their most complete assessment to date about how cells move.

To read more of the release, click here. Also, posted here.

Thursday, December 17, 2009

Freund honored by ASME for his contributions to materials engineering

Lambert Ben Freund, Ph.D., the Henry Ledyard Goddard university processor and a professor of engineering at Brown University (Providence, R.I.), was honored by ASME with the Society's Nadai Medal. He is being recognized for fundamental contributions to the mechanics of solids, dynamic fracture, stress waves in solids, computational mechanics, mechanics of thin films and mechanics of biological systems.

The Nadai Medal, established in 1975, recognizes significant contributions and outstanding achievements which broaden the field of materials engineering. The award was presented to Dr. Freund during the 2009 International Mechanical Engineering Congress and Exposition in Lake Buena Vista, Fla., Nov. 13 through 19.

Wednesday, December 16, 2009

Deoni using MRI imaging to study neurodevelopment in children

Two Brown Faculty To Study Brain Development in Infants and Children With Bipolar Disorder

Sean Deoni, assistant professor of engineering, and Dr. Daniel Dickstein, assistant professor of psychiatry, have each received funding from the National Institute of Mental Health to study brain development in children with bipolar disorder. They will collaborate on each other’s projects.

PROVIDENCE, R.I. [Brown University] — Two Brown University faculty members have received federal funding for innovative new neuroscience research projects focusing on brain development in infants and bipolar disorder in children.

Sean Deoni, assistant professor of engineering, plans to use his $2.5-million grant to study neurodevelopment throughout infancy and early childhood, from 2 months to age 5, using an MRI imaging technique at Brown he previously developed with colleagues.

Read more here.

Tuesday, December 15, 2009

Today Show highlights sleep meter invention

NBC's Today Show highlights a group of Brown students that developed a sleep meter now available on the market.

Visit msnbc.com for breaking news, world news, and news about the economy

Friday, December 11, 2009

Graduate Student Profiles

In an effort to highlight the remarkable graduate student research here at Brown Engineering, we are creating a series of profiles that will highlight their work. Below are previews, to see the full profile details, click here."The catchphrase of our lab is “Atoms to Autos,” which means that we work on incorporating basic scientific research that begins at the atomic scale into larger and larger scale models eventually making improvements to the design of new GM automobiles."

"My research interests concern the exploration of multiprocessing techniques for low-power embedded systems (like smartphones, game consoles, etc.), and the development of design methods to improve the yield of 3D integrated circuits."

"BrainGate2 is an investigational device that we hope will one day enable people with paralysis to control external devices, such as a computer cursor, simply by mentally attempting the motion, essentially turning thought into action."

"Lead is added to Sn solder in electronic devices to inhibit defects (called “whiskers”) which result in failures and a shorter product life. I’m trying to understand how lead prevents defects and to find an environmentally friendly replacement that works equally well."

"The end goal of the influenza project is to develop a small, low cost, sensitive microfluidic assay to detect the presence and type of influenza in patient samples. Ideally, this device would integrated several tasks normally done in a laboratory such that it could be used at the point of care."

To see the full profile details, click here.

Thursday, December 10, 2009

RI Elevator Pitch Competition

Professor Eric Suuberg reports that students from his ENGN 1930G Entrepreneurship course performed well in the Rhode Island Business Plan Competition’s Elevator Pitch Contest this week. The event took place at the new R.I. Center for Innovation and Entrepreneurship and is considered a preview to the 2010 Rhode Island Business Plan Competition.

The winner, Adam Leonard, a student in Suuberg's ENGN 1930G course is mentored by Dr. Jason Hack of the Brown Medical School in the development of a device to treat pediatric needle pain. In addition, there were three students presenting from the Program in Innovation Management and Entrepreneurship, and two students, Matt Doherty and Michael Kreitzer, were in the group of winners. Each of these teams is expected to do well in the actual business plan competition next semester.

More details are available here.

Providence Business New online edition that also described the outcome of the competition: See http://www.pbn.com/stories/46634.html

Friday, December 4, 2009

Undergraduate Research Profiles

Sharon Makava started at Brown as an engineer with health-related interests. Her initial interests led her to biomedical engineering, but she is now pursuing Chemical and Biochemical Engineering degree. Her interactions with her former concentration advisor, Professor Tripathi, led her to her current work in his lab. She is working on K103N mutation in the HIV virus with graduate student Kenny Morabito. They are working to isolate and amplify the mutation at low sample concentrations. The end goal is to develop a test diagnostic which will allow doctors to look for a drug resistance amongst their patients. Her current research will give her a strong foundation to pursue industry or academic directions in the future, but for now she says “she can’t imagine being anywhere else.”
Eli Fine understands the importance of being aware of your intentions when you speak. He gained this appreciation through a linguistics class he took as part of Brown's open curriculum elective options. He has not only gained a greater appreciation for the scientific world, but also anthropology, philosophy, psychology, and linguistics. His collaborative spirit fits well with the interdisciplinary group of mathematicians, engineers and biologists he researches with in his multiple research projects at Brown.
Carmichael Ong is an intricate mix of biologist, biochemist, and bioengineer. He has the network to prove it. Carmichael has worked on two large interdisciplinary research projects at Brown in his undergraduate career. He believes that the intimate atmosphere within Brown Engineering and the approachable faculty are major benefits to his future. He plans to continue as a researcher in his future career either in industry or academia. Regardless of which direction he chooses, he will understand how to network with top rate researchers in an interdisciplinary setting because of his experience at Brown.
Ben Howard understands what it would take to be a Mythbuster on the Discovery Channel. He understands engineering and science principles and appreciates photography and video production. As a cinematographer for BTV (Brown’s Television Station) he produces his own tv show. Beyond just being inspired to record the world around him in unique ways, Ben is a design-oriented engineer. He found his way to Professor Breuer’s lab after having him for Thermodynamics class. His summer work extended into a larger research project to create a prototype that can create liquid droplets out of oil – a humidifier of sorts for oil. In Breuer’s lab, they have learned to use photography to study the aerodynamics of bat flight. They can record two flash photographs and record the velocity based on the distance the droplets have traveled around the bat’s wings. Most of the science is stumped on how bats accomplish their flight patterns. The Mythbusters wouldn’t even be able to figure it out, but Ben and other Brown engineers will eventually.
Juri Minxha works at the interface between engineering and neuroscience. He came to Brown uncertain of what he hoped to accomplish during his four years here. He found that the introductory engineering courses gave him a chance to test drive all of the related engineering fields. He also used the open curriculum to his advantage and took neuroscience courses. This background led him to Professor Palmore’s lab where he works at the interface of electrical engineering and neuroscience. He understands the importance of this research and hopes to continue his scholarship in a graduate program.

Many of our students are awarded annually with Halpin awards for their interdisciplinary research. To read more about the Halpin awards and the students profiled, click here.

Tuesday, November 24, 2009

Formula SAE Team Midyear Update

Brown Formula SAE Team Midyear Update: The front half of the car is put together, the engine dynomometer is up and running in Prince Lab, and driver training with Anthony Ricci of Advanced Driving and Securities, Inc. is going well. Check out the team video!

Tuesday, November 10, 2009

Brown engineer wins top prize at AIChE

Above: First Place winner in the Food, Pharmaceutical and Biotechnology section, Allison Yorita.
Below: AIChE students (left to right): Andrea Jones, Lakshmi Madhavan, and Allison Yorita.
Chemical and Biochemical Engineering (CBE) students in the Brown chapter of the American Institute of Chemical Engineers traveled to Nashville, Tenessee to compete in the student poster competition. Professor Joseph Calo reports that "our CBE students have, once again, made a terrific showing against some very strong national competition."
Our AIChE student poster competitors included: in the Environmental category a junior working with Professor Calo, Lakshmi Madhavan; and in the Food, Pharmaceutical and Biotechnology category two seniors working with Professor Tripathi, Andrea Jones and Allison Yorita.
In the most competitive category "Food, Pharmaceutical and Biotechnology," out of the 71 best posters in the nation, our student Allison Yorita brings home the first place award. Indrek Kulaots reports that "the competition was the most competitive I have seen so far in previous years as long as I have been involved with AIChE."

Wednesday, October 14, 2009

Professor Webster's new patents and keynote addresses

Professor Thomas Webster will present at Family Weekend 2009 Faculty Forums, Saturday, October 17, 2009 9:30 A.M.-NOON

Implants Are Everywhere: Using Biotechnology to Improve Health - Thomas Webster - Times and locations will be listed in your registration packet. Seating is limited. Registration badge or Brown ID is required. To register and for more information, visit Family Weekend 2009.

NEWS: Two new patents issued for the Brown start-up company Nanovis, Inc. (http://www.nanovisinc.com/):

1. US Patent Application Serial No. 10/793,721 PLGA Substrate With Aligned and Nano-Sized Surface Structures And Associated Method
2. US Patent Application Serial No. 10/634,292 Nano-Structured Polymers For Use As Implants
Professor Webster will give two keynote addressess on Monday, October 19, 2009. One to celebrate the 5th anniversary of the Wake Forest Center for Nanotechnology and Molecular Materials at Wake Forest University (https://email.brown.edu/exchweb/bin/redir.asp?URL=http://pdc.wfu.edu/class/1120) and the other at Rensselaer Polytechnic Institute's NanobioTech 2009 (https://email.brown.edu/exchweb/bin/redir.asp?URL=http://www.alumni.rpi.edu/nanobio2009.html).

Addition to post:

One new patent will be issued on November 24, 2009:
US Patent Application Serial No. 7,622,129 Nano-structured Polymers for Use as Implants
The patent describes the fabrication process and benefits for using nanostructured polymers to increase tissue growth for a wide range of regenerative medicine applications.

Edible Car Challenge wtih Food Network coming soon...

Brown Engineering and Society of Women Engineers will again present the Edible Car Competition on October 30, 2009 at 3:00pm at Barus and Holley. Join us by creating your own team to compete or come cheer on the teams as they compete against the Food Network's Glutton for Punishment Bob Blumer.

The Glutton for Punishment show will highlight how Brown's green community participates in compost and usage of all food waste. We are looking forward to highlighting the strengths of our community!

To come test your creative skills and compete, email Holly_Lauridsen@brown.edu with your team of 3-5 people. You will then receive a list of complete rules.

Details from last year's Edible Car Competition:
http://today.brown.edu/articles/2008/04/food-car-race

Thursday, October 1, 2009

Alumni Dr. George Thurston '73 will present on Asthma and Diesel Air Pollution

Diesel Air Pollution and
Asthma in New York City

Presented by
Dr. George D. Thurston '73
Dept. of Environmental Medicine
NYU School of Medicine
Nelson Institute of
Environmental Medicine

Friday, October 2, 2009
12:00 PM
Barus & Holley
Room 190
Brown University
182 Hope Street
Providence, RI

Presented by the Superfund Research Program - www.brown.edu/sbrp

Childhood asthma is at near epidemic proportions in parts of New York City, affecting as many as one quarter of all elementary aged children in certain under-served minority neighborhoods of the city. There is also an increasing body of evidence indicating that living near to traffic is associated with increased respiratory problems in children. Exposure to fine particles from diesel vehicles is suspected as a likely causal agent in these associations between traffic and asthma, but there is only limited information relating personal exposures to diesel particles and health for individual children. This seminar introduces both the asthma problem in New York City and the recent evidence regarding asthma and diesel air pollution, and then presents recent in-press results of a study conducted by NYU in the South Bronx that has directly tested the relationship between childhood asthma symptoms and personal exposures to diesel particles. Options available to control diesel emissions in New York City and elsewhere are also discussed.

Professor Allan Bower publishes new book, Applied Mechanics of Solids


Professor Allan Bowers new book, Applied Mechanics of Solids, comes out today, October 1, 2009.

Applied Mechanics of Solids summarizes the physical laws, mathematical methods, and computer algorithms that are used to predict the response of materials and structures to mechanical or thermal loading.

Topics include: the mathematical descriptions of deformation and forces in solids; constitutive laws; analytical techniques and solutions to linear elastic and elastic-plastic boundary value problems; the use and theory of finite element analysis; fracture mechanics; and the theory of deformable rods, plates and shells.

Over 400 practice problems are provided on a companion web site, as well as demonstration finite element codes in MAPLE and MATLAB. The text is intended for advanced undergraduate or graduate students, as well as practicing engineers and scientists. It will be particularly useful to readers who wish to learn enough about solid mechanics to impress their teachers, colleagues, research advisors, or managers, but who would prefer not to study the subject in depth.

An electronic version of the text can be accessed at http://solidmechanics.org and its also available from Amazon.

Monday, September 28, 2009

Knowledge-based economy in RI

Kipp Bradford (Engineering Sc.B. '95 and Adjunct Professor) shares his participation in Rhode Island's Knowledge-based economy.

Friday, September 11, 2009

Summer Insights

Brown Engineers were involved in a variety of worthwhile projects this summer:

or visit:
http://www.youtube.com/user/brownengin

Meet our new faculty

Engineering welcomed three new faculty members recently. Read more about them:
Sean Deoni
http://today.brown.edu/faculty/2009/deoni
Christian Franck
http://today.brown.edu/faculty/2009/franck
Domenico Pacifici
http://today.brown.edu/faculty/2009/pacifici

Tuesday, September 1, 2009

Audio Insights: Nanovis developing nanosurface technology


Listen to audio excerpts from a recent highlight interview with Professor Thomas Webster talking about his start-up company Nanovis.

Nanovis' leaders say, depending on the type of conventional implant, up to five percent can become problematic because the body rejects it, recognizing it as a foreign object because its smooth surface doesn't match the rough surface features of human tissue. However, the nanosurfaced implants Nanovis is developing feature a "roughness" that mimics human tissue, allowing the body to "accept" them. Webster says the nanosurfaced implants decrease infection, reduce the growth of scar tissue and promote the growth of healthy tissue. Listen

Using the same core idea of mimicking the natural roughness of human tissue, Nanovis is developing nanosurface technology for orthopedic, spinal, dental, cardiovascular and soft tissue implants. Listen

"It's a pretty exciting time for me as a researcher and a pretty exciting time for this mysterious sounding field of nanotechnology. There's actually real world application for this field—not just the nano iPod!" laughs Webster. "There are actual medical devices and real clinical treatments that can benefit from nanotechnology."

Monday, August 17, 2009

Testing nanomaterials for safety

"Scientists are preemptively testing the potentially ill effects of the tiny molecules and even atoms engineered at the scale of one billionth of a meter or smaller."

Carbon nanoparticles appear to be benign when fed to fruit fly larvae, but adults exposed to the nanoparticles in powdery form are not as lucky. Research led by David Rand and Robert Hurt show two varieties of carbon nanoparticles stuck to the flies, impeded them from climbing and ultimately caused them to die.

See full article at Scientific American:
www.scientificamerican.com/article.cfm?id=carbon-nanomaterials-bad-for-fruit-fly-coating
See Brown news release: news.brown.edu/pressreleases/2009/08/nanotoxicity

Wednesday, August 5, 2009

Tissue engineering research at Brown

Codirector of Brown University’s Center for Biomedical Engineering, Jeff Morgan leads a team of scientists who have developed novel ways of forming individual cells into living tissue. Some day, their techniques, in combination with stem-cell technology, could cure or lessen the suffering of diabetes and other debilitating diseases.

Strictly speaking, Morgan is a tissue engineer –– one of a substantial number of scientists around the world who are learning how to create groupings of cells that mimic the function of tissues or organs. Formed in the laboratory, these tissues can be transplanted into living creatures. Research is still largely confined to experimental animals –– but success so far in mice and rats holds great promise for humans.

Morgan’s advance is his unique method of growing and assembling individual cells into larger clusters –– what he calls the potential “building blocks” of tissues and organs that could be produced on demand.

More from the Providence Journal here:
http://www.projo.com/news/content/tissue_man_08-03-09_O4F81UM_v10.3b3bef6.html

Thursday, July 30, 2009

Alumni develop sleep analyzer

In 2003, three Brown University undergraduates, Eric Shashoua, Ben Rubin and Jason Donahue, sat in a school cafeteria and mused about their grogginess after an all-night study session. They knew that the stress of exams played a role, but they started wondering about the science of their exhaustion.

Little did they imagine that their discussion would eventually lead to the founding of Zeo, maker of the first direct-to-consumer sleep device that analyzes nighttime sleep patterns. Zeo's product, the Personal Sleep Coach, uses a soft headband loaded with sensors to monitor brain waves. The data are sent wirelessly to a small device on a nightstand; from there they can be uploaded to the MyZeo.com Web site. MyZeo.com then analyzes the data and e-mails back a strategy and suggestions for improving the next night's sleep.

However, once these three would-be entrepreneurs decided to create a science-based aid for the estimated 70 million Americans suffering from chronic sleep disorders, they realized they were lacking a key ingredient: an investor--or several--to fund their research and development.

Initial fundraising began in the cafeterias at Brown. "We literally went table-to-table to talk about our innovation and get people interested in contributing," Shashoua recalls. Those discussions led to introductions to wealthy Brown alumni, experts in sleep research and so-called "angel investors."

More of the article on Forbes.com.